微囊藻毒素LR对大鼠肝细胞Caspase-3酶活性的影响
EFFECT OF MICROCYSTIN-LR ON CASPASE-3 IN RAT HEPATOCYTES
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摘要: 水体富营养化的加剧,导致藻类水华频频发生。在全球由于藻类水华所产生的毒素,对人和动物都产生了极为严重的影响,使之成为日益突出的环境问题。其中危害最严重的 是微囊藻毒素(Micnocystin,MCYST)。而微囊藻毒素LR(LR)是微囊藻毒素中存在最为普遍且毒性作用最明显的一种,是MCYST的主要代表物。
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Keywords:
- Capase-3 /
- Microcystin-LR /
- BRL-3A cells
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[1] Ding W X, Shen H M, Zhu H G et al.Studies on Oxidative Damage Induced by Cyanobacteria Extract in Primary Cultured Rat Hepatocytes[J].J Environ Res,1998,78:12-18[2] Ding W X,Ong C N.Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity[J].FEMS Microbiol Lett 2003,220(1):1-7[3] Yuan C Q,Ding Z H.The structure and function of caspase[J].Foreign med sci(molecular biology section)2002,24(3):146-151.[袁长青,丁振华,Caspase的结构与功能,国外医学分子生物学分册,2002,24(3):146-151][4] Fu W Y,Li M W, Xu L H et al.Detecerion of apoptosis of renal cells of mice induced by microcystin-LR[J].Acta Hydrobiologica Sinica.2004,28(1):101-102.[傅文宇,李敏伟,徐立红,等,一种检测微囊藻毒素LR诱导大鼠肾细胞凋亡的方法.水生生物学报2004,28(1):101-102][5] Fu W Y, Chen J P,Xu L H.The role of Caspase-3 in the apoptosis o induced by microcystin [J].China Environ Sci.2004,1.(in press)[傅文宇,陈加平,徐立红.Caspase-3在微囊藻毒素诱导的细胞凋亡中的作用,中国环境科学,2004,24(1):6-8] Ding W X, Shen H M, Zhu H G et al.Studies on Oxidative Damage Induced by Cyanobacteria Extract in Primary Cultured Rat Hepatocytes[J].J Environ Res,1998,78:12-18[2] Ding W X,Ong C N.Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity[J].FEMS Microbiol Lett 2003,220(1):1-7[3] Yuan C Q,Ding Z H.The structure and function of caspase[J].Foreign med sci(molecular biology section)2002,24(3):146-151.[袁长青,丁振华,Caspase的结构与功能,国外医学分子生物学分册,2002,24(3):146-151][4] Fu W Y,Li M W, Xu L H et al.Detecerion of apoptosis of renal cells of mice induced by microcystin-LR[J].Acta Hydrobiologica Sinica.2004,28(1):101-102.[傅文宇,李敏伟,徐立红,等,一种检测微囊藻毒素LR诱导大鼠肾细胞凋亡的方法.水生生物学报2004,28(1):101-102][5] Fu W Y, Chen J P,Xu L H.The role of Caspase-3 in the apoptosis o induced by microcystin [J].China Environ Sci.2004,1.(in press)[傅文宇,陈加平,徐立红.Caspase-3在微囊藻毒素诱导的细胞凋亡中的作用,中国环境科学,2004,24(1):6-8]
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